Abstract
Rikshospitalet, U of Oslo, Norway. HO has been suggested as a risk factor for kernicterus. Free radicals may be involved in oxygen toxicity. HX 10mM was infused at 0.1ml/min for 30min into retrograde carotid catheters in awake, young, male SPRD rats. The infusion was then briefly interrupted to inject XO 1U/kg through the same catheter, and the HX infusion continued at half the initial rate for another 30min. In group I (controls) 0.9% NaCl was infused instead of HX/XO. Groups I and II breathed 21% O2 at all times, while group III breathed 90% O2 from the start of the experiment. After 60min all groups were given a bolus dose of 125I-HSA through a peripheral venous catheter, followed by B 25mg/kg for 5min, then B 35mg/kg for 55min. Brain B was determined by chloroform extraction, and brain A by gamma counting. There were no significant differences between the groups as regards serum B, serum A, brain B, or brain A. HO, HX, and XO do not increase the entry of B or A into rat brain.
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Hansen, T., Poulsen, J., Saugstad, O. et al. 47 HYPEROXIA (HO), HYPOXANTHINE (HX) AND XANTHINE OXIDASE (XO) DO NOT INCREASE THE ENTRY OF BILIRUBIN (B) OR ALBUMIN (A) INTO YOUNG RAT BRAIN. Pediatr Res 24, 268 (1988). https://doi.org/10.1203/00006450-198808000-00073
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DOI: https://doi.org/10.1203/00006450-198808000-00073