Abstract
In kernicterus the concentration of B is higher in cerebellum and basal ganglia than in other parts of the brain. The mechanism for this is unknown. We have studied the entry of B during short-term (1hr) hyperbilirubinemia created by infusing 3H-B into young, male SPRD rats. Some rats were given sulfisoxazole 50mg/kg to displace B from the binding to A, some rats were made hypercarbic (PCO2 18-21kPa, pH 6.9), and some rats were made hyperosmolar (serum osmolality 400mosm/l). The brains were dissected into 7 regions: cerebral cortex, hippocampus, striatum, midbrain, hypothalamus, cerebellum, and medulla oblongata. After correcting for B remaining intravascularly, interregional differences in brain B were not significant under any of the conditions employed. Differences in B concentrations between brain regions in kernicterus may not be related to differences in B uptake.
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Hansen, T., øyasæter, S., Stiris, T. et al. 46 LACK OF REGIONAL DIFFERENCES IN ENTRY OF BILIRUBIN (B) INTO YOUNG RAT BRAINS DURING CONTROL, DISPLACER, HYPERCARBIC, AND HYPEROSMOLAR CONDITIONS. Pediatr Res 24, 268 (1988). https://doi.org/10.1203/00006450-198808000-00072
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DOI: https://doi.org/10.1203/00006450-198808000-00072