Abstract
BE was induced in 6 weeks old male SPRD rats by a 3hr infusion of B, resulting in mean serum B levels of 133-183μmol/l. Controls were infused with B-free solvent. Two hours into the infusion period some rats were given sulfisoxazole 50mg/kg as a bolus dose, others were given carbamide 75mmol/kg as a bolus dose, and yet others breathed 20% CO2 in air for the last hour of the infusion period. Three weeks later behavioral studies in an open-field apparatus demonstrated changes in the B-treated rats interpreted as indicative of changes in stimulus processing. After fixation in 4% formaldehyde, sections from the brains of 68 rats were stained with hematoxylin-eosin and studied with light-microscopy by a pathologist (BW) who was blinded to the preceding treatment of the rats.
Evidence of neuronal loss or glial proliferation was not found in any of the brains, indicating that BE manifesting itself with changes in behavior may occur without discernible microscopic changes in the brain.
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Hansen, T., Westre, B., Sagvolden, T. et al. 45 LACK OP HEUROPATHOLOGICAL CHANGES AFTER BILIRUBIN (B) ENCEPHALOPATHY (BE) IN RATS. Pediatr Res 24, 268 (1988). https://doi.org/10.1203/00006450-198808000-00071
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DOI: https://doi.org/10.1203/00006450-198808000-00071