Abstract
The effect of oxygen radicals on the pulmonary circulation in pigs was studied. A bolus infusion of xanthine oxidase (XO) was given with or without hypoxanthine (Hx) into the right atrium. Pulmonary artery pressure (PAP) and pulmonary flow (PAQ) were measured continuously, and the pulmonary resistance (PR) was calculated. Three groups were studied: 1) Pigs given XO (1 U/kg). 2) Pigs given XO combined with Hx. 3) Pigs pretreated with indomethacin (7.5 mg/kg) before infusion of XO. Results: The table shows absolute differences from baseline values 20 minutes after XO was administered.
Infusion of XO both with and without Hx gave a significant increase in PAP and PR with PAQ decreasing concomitantly. Animals pretreated with indomethacin did not show any significant differences from baseline levels. This study demonstrates that XO potently constricts the pulmonary circulation in pigs. Since pretreatment with indomethacin only gives a blunted response, the effect may be mediated by the prostaglandin system.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sanderud, J., Norstein, J. & Sauqstad, O. 24 OXYGEN RADICALS PRODUCE PULMONARY HYPERTENSION IN PIGS. Pediatr Res 24, 264 (1988). https://doi.org/10.1203/00006450-198808000-00050
Issue Date:
DOI: https://doi.org/10.1203/00006450-198808000-00050