Abstract
31P MRS was used to investigate disruption of brain energy status by a combination of hyperbilirubinaemia and an open blood-brain barrier (BBB). Spectra were acquired using a surface coil over the right cerebral hemisphere of anaesthetised adult male rats. Observations were made before and after intravenous infusion of bilirubin (BR, 5.2mM, 10ml in 400μM bovine scrum albumin) or a control albumin solution, and after hyperosmolar BBB opening with l-arabinose (1.8 Molal) infused via the right external carotid artery over 20s at 7.5ml/min. Results are expressed as the ratio of phosphocreatine (PCr) to PCr + inorganic phosphate (Mean ± SD).
These observations provide evidence in vivo that bilirubin affects cerebral energy metabolism in the presence of an open BBB.
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Ives, N., Bolas, N. & Gardiner, R. 20 BILIRUBIN NEUROTOXICITY AND BLOOD-BRAIN BARRIER OPENING IN THE RAT STUDIED USING 31 P MAGNETIC RESONANCE SPECTROSCOPY ( 31P MRS). Pediatr Res 24, 264 (1988). https://doi.org/10.1203/00006450-198808000-00046
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DOI: https://doi.org/10.1203/00006450-198808000-00046