Abstract
A toxic serum factor isolated from sera of DMD patients could be shown to increase the membrane fluidity of DMD and control lymphocytes [Hübner C et al. (1987) Pediatr Res 22:488-492]. We have recently found that isolated DMD lipoproteins have the same effect. Fluorescence anisotropy of diphenylhexatriene in peripheral blood lymphocytes (PBL) was significantly decreased when PBL were incubated for 4 h in DMD lipoproteins as compared to 4 h incubation in control lipoproteins (r=0.168±0.007, n=10 vs. r=0.182 ±0.012, n=9; p<0.02, Mann-Whitney test). Similar results could be obtained after incubation of PBL in the isolated LDL fraction of DMD lipoproteins versus control LDL (r=0.190±0.011, n=9 vs. r=0.206±0.007, n=7; p<0.02). Therefore, the LDL fraction seems to be mainly responsible for the increase of PBL membrane fluidity in DMD patients.
(Supported by DFG grant Ko 756/1-III)
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Hübner, C., Kohlschütter, A., Wiehler, U. et al. 11 MEMBRANE TOXICITY OF DUCHENNE MUSCULAR DYSTROPHY (DMD) SERUM IS LIPOPROTEIN‐BOUND. Pediatr Res 24, 262 (1988). https://doi.org/10.1203/00006450-198808000-00037
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DOI: https://doi.org/10.1203/00006450-198808000-00037