Abstract
In association with impaired tissue perfusion or sepsis factors affecting blood pressure, vascular permeability and cell lysis are released. Several observations indicate that they are some of the factors leading to ARDS and hemolysis, responsible for the anemia in these diseases.
Material and Methods: CPD blood was perfused within the ECMO equipment in six different experiments. Blood samples were analysed before start of ECMO, 5 minutes, 12, 24 and 40 hours after start. C3a and C5a were determined by a RIA method. Membrane attacking complexes were measured by an Eliza technique.
Results: During ECMO perfusion as well C3a and C5a as plasma hemoglobin, as the concentration of membrane attacking complexes, rose with time (p <0.05).
Conclusion: The results indicate accumulation of anaphylatoxins as well as products resulting from cell injury as membrane attacking complexes. They can influence blood pressure and anemia during the ECMO procedure. When occuring in a situation without calcium blockade, as in vivo., an even more profound formation of these substances will appear in a time dependent fashion.
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Friberg, L., Mellgren, C., Bengtsson, A. et al. 6 LIMITING FACTORS IN PROLONGED ECMO TREATMENT BY IMMUNOLOGICAL INTERFERENCE. Pediatr Res 24, 261 (1988). https://doi.org/10.1203/00006450-198808000-00032
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DOI: https://doi.org/10.1203/00006450-198808000-00032