Abstract
ABSTRACT: Regional brain glucose utilization was investigated by positron emission tomography with fluorodeox-yglucose in three children with adenylosuccinase deficiency. A consistent pattern was found in the three patients, namely a marked decrease of fluorodeoxyglucose uptake in all gray structures, with the exception of the cerebellum, which was minimally affected. Anomalies predominated in the cerebral cortex, particularly in the anterior regions; they were less pronounced in thalamus and basal ganglia. The observations suggest that positron emission tomography may be a useful tool for the localization of the deleterious effects of metabolic diseases and for the investigation of their pathophysiologic mechanisms.
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De Volder, A., Jaeken, J., Den Berghe, G. et al. Regional Brain Glucose Utilization in Adenylosuccinase-Deficient Patients Measured by Positron Emission Tomography. Pediatr Res 24, 238–242 (1988). https://doi.org/10.1203/00006450-198808000-00020
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DOI: https://doi.org/10.1203/00006450-198808000-00020
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