Abstract
ABSTRACT: We measured plasma immunoreactive (IR)-7B2 concentrations in 96 children (57 males and 39 females) from the newborn period to 20 yr of age. Plasma IR-7B2 concentrations in infants less than 2 yr of age (range 175–580 pg/ml, n = 19) were much higher than those in adults (range 20–138 pg/ml). Plasma levels of IR-7B2 decreased with age during childhood to reach the adult level at 15–20 yr. Significant negative correlations were found between plasma levels of IR-7B2 and dehydroepiandrosterone sulfate (r = −0.4154, p < 0.05, n = 27), luteinizing hormone (r = −0.4948, p < 0.05, n = 20) and follicle-stimulating hormone (r = −0.4682, p < 0.05, n = 20). The possibility of a relationship between the reduction of plasma IR-7B2 levels and pubertal development warrants attention.
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Iguchi, H., Niida, Y., Natori, S. et al. Remarkable Changes in the Plasma Levels of Pituitary Protein “7B2” during Childhood. Pediatr Res 24, 194–196 (1988). https://doi.org/10.1203/00006450-198808000-00011
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DOI: https://doi.org/10.1203/00006450-198808000-00011