Abstract
In previus studies on exercise–induced hyperuricemia, we have reported that serum uric acid (UA) increases at 1–2 through 24 hours after an exhaustive exercise in human subjects, and that plasma oxypurine levels increase 1 through 7 hours after the end of an exhaustive exorcise in human subjects taking allopurinol. To study the mechanism of such prolonged exercise–induced hyperuricemia, we have used an animal model in this study. The maximal physical activity was enforced for 21 minutes on a treadmill to adult male Wislar rats to which allopurinol was administered beforehand. The concentrations of purine metabolites in plasma and muscle were assayed, by HPLC. Plasma UA was consistently low due to the administration of allopurinol. Plasma hypoxanthine (HX) and xanthine reached the peak, respectively, at 5 and 30 min, and they showed respectively, a higher tendency and a statistically higher level compared to the control rats without an exercise for 5 hours. In plantaris muscle, ATP decreased with increased IMP at 5 min. Inosine (Ino) increased significantly at 5 min and showed a higher tendency for I hour. HX increased significantly at 5 min through 2 hours. These data suggest that the production of HX from Ino in skeletal muscle persists after the end of an exhaustive exercise leading to the continuous release of HX lo blood for at least 2 hours. Based on these, it is concluded that persistent production of HX in skeletal muscle even after the end of an exhaustive exercise is responsible for prolonged exercise–induced hyperuricemia.
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Ogasawara, M., Seino, T., Hadano, S. et al. 100 PERSISTENT PRODUCTION OF HYPOXANTHINE IN RAT SKELETAL MUSCLE CAUSES PROLONGED HYPER —URICEMIA AFTER AN EXHAUSTIVE EXERCISE. Pediatr Res 24, 127 (1988). https://doi.org/10.1203/00006450-198807000-00124
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DOI: https://doi.org/10.1203/00006450-198807000-00124