Abstract
The aim of this study was to examine whether pyrazinamide and allopurinol were metabolized in three xanthinuric patients of two families of hereditary xanthinuria lacking xanthine oxidase because we were interested in whether both pyrazinamide and allopurinol were oxidized only by xanthine oxidase or by other kinds of oxidase. A xanthinuric patient, the propositus of a family of xanthinuria could neither metabolize pyrazinamide into 5-hydroxypyrazinamide nor allopurinol into oxypurinol. Two xanthinuric patients, the propositus of the other family of xanthinuria and his elder brother could metabolize both pyrazinamide into 5-hydroxypyrazinamide and allopurinol into oxypurinol. These results suggests that xanthinuria consists of at least two subgroups; one does not possess pyrazinamide-allopurinol oxidizing enzyme(s) other than xanthine oxidase or possesses a variant form of xanthine oxidase which can neither metabolize oxypurines nor pyrazinamide or allopurinol, and the other possesses pyrazinamide-allopurinol oxidizing enzyme(s) or possesses the other variant form of xanthine oxidase which can not metabolize oxypurines but can do both pyrazinamide and allopurinol.
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Higashino, K., Yamamoto, T., Hada, T. et al. 57 STUDIES ON THE METABOLISM OF PYRAZINAMIDE AND ALLOPURINOL IN PATIENTS WITH HEREDITARY XANTHINURIA. Pediatr Res 24, 120 (1988). https://doi.org/10.1203/00006450-198807000-00081
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DOI: https://doi.org/10.1203/00006450-198807000-00081