Abstract
Pseudomonas awruginosa (Psa) pneumonia is accompenied by extensive lung tissue damage. With the aim of preventing tissue damage thus preseving respiratory function, the use of anti-inflamatory drugs has been suggested for pediatric patients. In this study we investigated the effect of the treatment with a non steroidal anti-inflamatory agent piroxicam on lung inflamation induced by Psa. Swiss mice were treated with 0.04, 0.16, 0.64 2.56 mg/kg piroxicam per day intraperitoneally. Control mice received saline. After a 4-day treatment the animals were exposed to an aerosol containing Psa, and 6 - 8 × 106 colony forming units of Psa were deposited in each animal's lungs. The mortality rate of the control group was 63%, whereas mortality decreased in a dose-response fashion in piroxicam-treated mioe; the rates were 53, 24, 6 and 22% respectively for the doses shown above. Histopathology revealed amelioration of lung inflamation with piroxicam doses of increasing magnitude. Perivascular infiltration was diminished significantly in a dose-response fashion. Peribronchial infiltration was also diminished although less significantly. This study confirms the results of our previous investigation using ibuprofen. Since defense mechanism of the host against Psa remained unaltered after anti-inflamatory treatment, we conclude that non-steroidal anti-inflamatory agents may be a useful adjunct therapy for the treatment of Pseudomonas pneumonia.
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Sordelli, D., Cerequetti, M., Fontán, P. et al. 30. THE EFFECT OF NON-SIERLOIDAL ANTI -AMATORY AGENIS IN BACTERIAL PNELMONIAS ITS SIGNIFICANCE IN PEDIATRICS. Pediatr Res 23, 652 (1988). https://doi.org/10.1203/00006450-198806000-00053
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DOI: https://doi.org/10.1203/00006450-198806000-00053