Abstract
The amount fo breath H2 produced during the following 6 hours after the ingestion of a 240 volume of milk was used as an index of the rate of colonic fermentation of undigested lactose in 8 lactose malabsorbers guatemalan adults. Challenge included on separate days: milk alone, milk with 400 g of cooked beef added; lactose prehydrolized milk (Lactaid r) with 400 g of cooked beef; cooked beef alone, or fasting through the 6 hours of study. The excess excretion volumes of breath H2 with the respective treatments, calculated as the mean area under the curve were higher (178 ± 31.1 ppm.h) with milk alone than milk plus beef (50 ± 17), or prehydrolyzed milk (-1 ± 26.5) (p < 0.0001). The peak increments showed similar trends, with the 8 subjects over 20 ppm of breath H2 with milk alone, 2 out of 8 with milk and beef and none with hydrolized milk, beef or fasting. Mean peak increment were 38.6 ± 13.4; 12.1 ± 8.8 and 3.8 ± 3.2 for milk, milk and beef or hydrolized milk, respectively. Thus cooked beef significantly reduces the rate of appearance of intact lactose in the large bowel of lactose deficient adults.
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Castillo-Dur´n, C., Guerrero, A. & Solomons, N. 17. STUDIES ON THE COLONIC FERMENTATION OF LACTOSE IN HUMANS: THE EFFECT OF COOKED BEEF ON A SIGLE GLASS OF MILK. Pediatr Res 23, 650 (1988). https://doi.org/10.1203/00006450-198806000-00040
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DOI: https://doi.org/10.1203/00006450-198806000-00040