Abstract
The associations of Hashimoto's goitrous thyroiditis with HLA-DR5, atrophic thyroiditis with DR3, postpartum thyroiditis with DR4 and Grave's disease with DR3 have been described. We studied HLA-A, B, C, DR antigens, C4 and Bf types and thyroid function in 64 patients with JAIT. 45 of them were young adults with a mean follow-up of 10.6 years (J Pediatr 1985;107:898), others were 9.6–17-5 years of age and were followed for 2.3 (0.5-8.5) years. The HLA-DR antiaen frequencies in patients (and controls) were: DR1 20% (37%) P < 0.01, DR2 24% (33%), DR3 32% (32%), DR4 54% (27%) P < 0.001, DR5 3% (6%), DR6 10% (5%), DR7 14%(l7%) and DR8 3% (13%) P < 0.05. Euthyroidism was found in 53%, subclinical hypothyroidism in 14% and clinical hypothyroidism in 33% of the patients. Circulating antimicrosoma1 antibodies (Msab) (titre ≥ 400) were present in 73% and antithyroglobulin antibodies Ttitre ≥ 400) in 38%. Of the 17 patients with absent or low tit-re Msab 16 were euthyroid (P < 0.001) and 13 of them were DR4 positive ( P < 0 .05).
Conclusion: JAIT is highly significantly associated with HLA-DR4 and euthyroidism with absent or low Msab titre.
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Mäenpää, J., Raatikka, M., Partanen, J. et al. JUVENILE AUTOIMMUNE THYROIDITIS (JAIT) IS ASSOCIATED WITH HLA-DR4. Pediatr Res 23, 134 (1988). https://doi.org/10.1203/00006450-198801000-00198
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DOI: https://doi.org/10.1203/00006450-198801000-00198