Abstract
Neonatal screening for hypothyroidism was instituted in our region of France in 1977 and since then 52 cases have been detected.
Study of psychomotor development was carried out using Griffith's last from 1 to 5 years and the wise from 6 years onwards in the hypothyroid children and 110 control subjects. In the hypothyroid group, the global development quotients (GDO) were normal : 96.6 ± 1.2 at, 1 yr (n=42), 100.9 ± 2.2 at 3 yrs (n=29) and 98.7 ± 2.9 at 5 yrs (n=21). There was no significant difference with the control group. Analysis of partial DQ showed that scores were stable for posture, coordination, sociability and performance, but there was a transitory decline in language at 2 yrs. Between 6 and 8 yrs, mean IQ was 101.7 at 6 yrs (n=13). Tne results were within the norm for the test. A neurological examination assessed using TOUWEN'S criteria was carried out at 6 months, 1, 2, 4 and 6 years of age. Tne result showed a lower level of coordination and precise movement control which was significant as coat-pared to the control group. These results were confirmed by Lincoln-Oseretsky's test carried out at the age 7 years.
The overall results were analyzed to discover any correlation with the gravity or duration of the condition (blood thyroid hormone levels, etiology, epiphyseal area). There was a good correlation between the DQ at 6 months, 2 and 3 years of age, and the epiphysis area at the time the condition was detected, whereas there was no difference between athyrosis and ectopic thyroid cases.
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Rogé, B., Alexandre, F., Moron, P. et al. AN EIGHT-YEAR STUDY OF THE MENTAL AND PSYCHOMOTOR DEVELOPMENT OF HYPOTHYROID CHILDREN DETECTED BY NEONATAL SCREENING. Pediatr Res 23, 132 (1988). https://doi.org/10.1203/00006450-198801000-00187
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DOI: https://doi.org/10.1203/00006450-198801000-00187