Abstract
Five children (2 M, 3 F) aged 3.5-9.5 yrs, with central precocious puberty and 1 boy (12 yrs old)with corpus callosum agenesis and sexual aggressive behaviour, have been treated with LH-RH Analogue (Buserelin): a)First 15 days:30±10% mcg/Kg/die subcutaneously; b)Later:1200 mcg/die intranasal, via nebulizer in 3 doses. Each child was assessed for a complete hormonal picture, particularly: a)LHRH test and sexual steroids(Ria method);b)Biological and radioimmunological assay for LH(-30′, -15′, 0)and the mean of the biological/immunoreactive LH ratio(B/I;prepubertal values <0.6) (Fraioli et al.J.Endocrinol.Invest.8:513, 1985). Our results, both clinical and biochemical, returned to normalprepubertal condition at 1 month until the 3rd mo. After this time, they showed an escape of B/I ratio, raising at 2.8(6 mo);2.16(4 mo); 3.1 (4 mo);2.7(12 mo) in spite of persisting normalization of clinical findings and sexual steroid levels. These results can be attributed to an inadequate or discontinuous absorption during the intranasal administration or to a hypothetical change of LH native molecule, occurring during long-term treatment. The elevation of B/I seems to represent an early useful monitor for a new assessment of dosage or route of administration.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Borrelli, P., Crino, A., Cambiaso, P. et al. LH-RH ANALOGUE TREATMENT OF CENTRAL PRECOCIOUS PUBERTY: MONITORING BY BIOLOGICAL ASSAY FOR LH. Pediatr Res 23, 128 (1988). https://doi.org/10.1203/00006450-198801000-00162
Issue Date:
DOI: https://doi.org/10.1203/00006450-198801000-00162