Abstract
C- reactive protein (CRP) levels were investigated in 8 cases of Kawasaki disease (KD) all treated with high doses of intravenous gammaglobulin (400 mg/kg) for 3 days). Medium initial value of CRP was 190 mg/100 ml (range 129-284). The delay between the onset of the disease and treatment was 12.5 days (5-24). In all cases CRP normalized dramatically with a mean delay of 3.5 days (range 0-7 dys) after the end of treatment. This biologic parameter normalized before other inflammatory tests, such as erythrocyte sedimentation rate, platelet count, fibrlnogen and IgE. Both apyrexia occured and skin lesions evolution stopped. One patient with coronary artery involvement was treated after a delay of 24 days when cardiac lesions were already present. CRP value was normal 24 hours after the onset of treatment and coronary lesions stabilized. Monitoring of CRP appears to be an accurate index in clinical practice. Furthermore dramatic normalization of CRP should be considered of interest in immunoglobulin efficacy and in indirect approach of KD pathophysiology.
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Boulloche, J., Mallet, E. & Pollet, F. 9. C-REACTIVE PROTEIN IN KAWASAKI DISEASE. Pediatr Res 24, 654 (1988). https://doi.org/10.1203/00006450-198811000-00031
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DOI: https://doi.org/10.1203/00006450-198811000-00031