Abstract
In November 1984 Furusho et al published their results suggesting that IV IGG prevents coronary artery aneurysm formation in Kawasaki Disease. These results were confirmed in an open controlled multicenter study by Newburger et al in 1986. In Finland new cases of KD have been registered since 1981. To determine the value of IV IGG in Finnish KD patients the records of patients registered in 1985-87 were reviewed. Seventy-one patients were registered. Data on both treatment and findings of coronary echocardiography were available on 63 patients. Coronary aneurysms were detected in 3/44 patients treated with aspirin + IV IGG and 3/19 patients treated with aspirin only. Two of the untreated children with aneurysms fulfilled only 4 of the 6 criteria of KD. These data are in accord with the suggested benefit of IV IGG in preventing aneurysm formation in KD. When treating Kawasaki patients with IV IGG we are facing the following problems:
- patients with diseases other than KD will be treated;
- KD patients not fulfilling the criteria will not be treated or their treatment will be delayed;
- an occasional patient with IgA deficiency will be treated;
- the final diagnosis may be obscured as the treatment modifies the clinical picture and invalidates the results of bacterial and viral serology.
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Salo, E. 8. INTRAVENOUS IMMUNOGLOBULIN IN KAWASAKI DISEASE. Pediatr Res 24, 654 (1988). https://doi.org/10.1203/00006450-198811000-00030
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DOI: https://doi.org/10.1203/00006450-198811000-00030