Abstract
We have previously shown that iodine overload induced in newborn infants by skin disinfection of the mothers with povidone iodine (PVP-I) for epidural anesthesia or cesarian section, transiently impaired neonatal thyroid function, especially in case of breast-feeding, and resulted in an elevated recall rate at screening for CH. Therefore, PVP-I was replaced in obstetrics by a non iodinated disinfectant (Chlorhexidine 0.5 % in isopropranolol 70 % (CHL)). We compared neonatal TSH (mU/L serum) at screening for CH before (4912 newborns) and after (1164 newborns) replacement of PVP-I by CHL in breast and bottlefed infants born to mothers with (groups 2) or without (groups 1) skin disinfection.
Results : (**p < 0,01 as compared to groups 1)
In conclusion, the substitution of PVP-I by CHL in mothers at delivery prevents transient impairment of neonatal thyroid function and results in a drastic decrease in the recall rate at screening for CH. Iodine overload is a significant and often unrecognized cause of “false positives” at screening and should be carefully avoided whenever possible.
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Chanoine, J., Bourdoux, P., Pardou, A. et al. 168 WITHDRAWAL OF IODINATED DISTINFECTANTS IN OBSTERICS DECREASES THE REQUENCY OF “FALSE POSITIVES” AT SCREENING FOR CONGENITAL HYPOTHYROIDISM (CH) IN NEWBORNS. Pediatr Res 24, 545 (1988). https://doi.org/10.1203/00006450-198810000-00189
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DOI: https://doi.org/10.1203/00006450-198810000-00189