Abstract
Regular testicular function and responsiveness of target organs to testicular androgens are prerequisites of normal male sexual development. Impairment of either function can cause varying degrees of incomplete mascullnization. A pilot study had revealed a different SHBG-reaction to anabolic steroids in patients with the testicular feminization syndrome (ESPE'87, Abstr.No.160). We now investigated the effect of Stanozolol and Oxandrolone (3 days 0.2 mg/kg per os) on SHBG, CBG, TBG, albumin, total protein, testosterone, estradiol, thyroxin, Cortisol, LH and FSH in 4 patients with Impaired testicular function (gonadal dysgenesis, 17β-hydroxysteroid-dehydrogenase defect), 4 patients with target organ insensitivity (partial and complete androgen resistance), and in 20 controls. In testicular dysfunction and in the controls SHBG-levels decreased significantly (p<0.001) down to a minimum of 61.6 % ± 6.0 (SD) (Stanozolol) and 66.2 ± 10.3 (SD) (Oxandrolone) of the initial values at days 5, 6, 7, or 8 after initiation of the test, while in partial androgen resistance the decrease was moderate (81% and 89%), and absent in complete testicular feminization. Differences In all other parameters were not statistically significant.
Conclusion: 1.) The SHBG-decrease induced by short term anabolic steroid application is a specific reaction. 2.) This reaction requires regular target tissue sensitivity. 3.) It can be used for the differentiation of testicular dysfunction syndromes from androgen insensitivity syndromes.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sinnecker, G., Köhler, S. & Willing, R. 147 FRG IMPAIRED SEXUAL DEVELOPMENT DUE TO TESTICULAR DYSFUNCTION AND TRAGET ORGAN INSENSITIVITY. DIFFERENTIATION BY A NEW ANDROGEN SENSITIVITY TEST. Pediatr Res 24, 541 (1988). https://doi.org/10.1203/00006450-198810000-00168
Issue Date:
DOI: https://doi.org/10.1203/00006450-198810000-00168