Abstract
Fifteen girls with CPP who have been treated with D-TRP-6-LH-RII (13 daily s.c.; 2 monthly i.m.) for 1 to 5 yrs were followed after therapy for 6 months to 4 yrs. Resumption of pubertal developmont was evident clinically 2 to 4 months after therapy was stopped and menstruation appeared after 3-6 months in 13 and after 2 yrs in one. In all growth velocity increased in parallel to pubertal reactivation and bone maturation advanced at a moderate rate. So far 8 girls have reached their final height.
Our data indicate that Cn-RH analog therapy in CPP has a beneficial effect on final height when started at an early bone age. The genetic stature is also a determining factor in final height.
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Kauli, R., Kornreich, L. & Laron, Z. 135 PUBERTAL DEVELOPMENT AND FINAL HEIGHT IN CIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP) AFTER THERAPY WITH THE Gn-RII ANALOC D-TRP-6-LII-RII. Pediatr Res 24, 539 (1988). https://doi.org/10.1203/00006450-198810000-00156
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DOI: https://doi.org/10.1203/00006450-198810000-00156
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