Abstract
Metabolic consequences of infusing lipids have been widely investigated. We evaluated the local effects of varying the proportions of parenteral glucose and fat on the venous tolerance or patency of infusion sites. Thirty-two observations were made in 16 infants; (X±SEM, birthweight:2.15±0.1 kg, gestational age: 34± 1 wk).In a paired cross over design the patients received for a given level of energy (60 vs 80 kcal/kg/d), two 6 day isocaloric and isonitrogenous (434±3.4 mg/kg/d, n=32) regimens differing only by the fat intake (LIP-1: 1.03±0.02, LIP-3: 2.78±0.05 g/kg/d). Minutes between changes in infusion sites (T), and osmolarity of the mixtures (Osm, mOsm/1) were compared between each treatment.
These data show that the lipid emulsion significantly reduces the final osmolarity of the mixture and thereby increases the patency of the infusion sites. Moreover, for a same osmolarity and glucose intake, the addition of lipids (60 kcal LIP-1 vs 80 kcal LIP-3) increases the infusion time significantly (p<0.05). Whether biochemical or physical, this protective effect of the lipid emulsion demonstrates that the quality of fuel mixtures has an important role on the patient's comfort.
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Pineault, M., Piedboeuf, B., Bisaillon, S. et al. CLINICAL BENEFITS OF CO-INFUSING A LIPID EMULSION WITH AMINO ACIDS-DEXTROSE SOLUTIONS IN NEWBORN INFANTS. Pediatr Res 21 (Suppl 4), 275 (1987). https://doi.org/10.1203/00006450-198704010-00649
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DOI: https://doi.org/10.1203/00006450-198704010-00649