Abstract
ABSTRACT. This study examines the responses of pial arterioles and venules to increased mean airway pressure (Paw) in newborn pigs. We further characterized the changes in cortical subarachnoid cerebrospinal fluid prostanoids with increased Paw, both before and after cyelooxygenase inhibition with indomethacin. Eight chloralose anesthetized newborn pigs were equipped with closed cranial windows and ventilated with a conventional infant pressure-cycled respirator. Increasing Paw from 3.2 ± 0.3 cm water to 14.3 ± 0.6 cm water did not change pial arteriole or venule diameters. Cerebrospinal fluid prostanoids (6–keto- TxB2, PGE2, and ), however, were increased reversibly (3- to 5-fold) by increasingPaw After indomethacin (5 mg/kg, intravenous) pial arterioles constricted approximately 15% with increased Paw. These results suggest that increasing ventilation pressure increases brain prostanoid production. Prostanoids appear to inhibit vasoconstriction and may be important in maintaining cerebral blood flow during the stress of mechanical ventilation.
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Mirro, R., Armstead, W., Busija, D. et al. Increasing Ventilation Pressure Increases Cortical Subarachnoid Cerebrospinal Fluid Prostanoids in Newborn Pigs. Pediatr Res 22, 647–650 (1987). https://doi.org/10.1203/00006450-198712000-00006
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DOI: https://doi.org/10.1203/00006450-198712000-00006