Abstract
With the aim to study the relationship between malnutrition, essential fatty acid (EFA) intake, renal production of prostaglandin (PC's) and renal function, we have measured urinary PGE2 and PGF2α by RIA, urine and serum electrolytes, creatinine clearance, plasma renin activity (PRA) and EFA in serum phospholipids by gas chromatography in 15 children aged 1 to 3 years and severely malnourished (marasmic kwashiorkor, wasting index <80%).
Results: (x ± SEM):
A = at admission; low EFA intake according to dietary history; B = after 10 days of equilibration diet containing 15% of calorie intake as linoleic acid. Urinary PG's were lew in 5 patients (E2) and elevated in 2 (E2 and F2α). No correlation was found between PG's and UV, UNa or PRA. A small but significant correlation was found between log PG and Ccreat. In severe malnutrition EFA intake seems not to affect PG synthesis at the renal level.
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Godard, C., Munoz, M., Vallotton, M. et al. URINARY PROSTAGLANDIN EXCRETION IN SEVERE MAINUTRITION. Pediatr Res 22, 372 (1987). https://doi.org/10.1203/00006450-198709000-00048
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DOI: https://doi.org/10.1203/00006450-198709000-00048