Abstract
ABSTRACT.: The ontogenesis of elastin (desmosine), collagen (hydroxyproline), and DNA concentrations and their rates of increase were studied in fetal sheep lungs from day 60 until term. Elastin increased 13-, 17-, 63- and IIfold in nondissected parenchyma, dissected (free of tubular structures of >0.1 mm diameter) parenchyma, pleura, and trachea, respectively. Collagen increased 2.1-, 1.8-, 5- and 3-fold, respectively, in the four tissues. A sharp rise in elastin occurred after day 100. The rate of increase in elastin was greater in dissected than in nondissected parenchyma while the reverse was true for collagen. The steepest rise of elastin concentration occurred in the pleura after day 125. DNA concentration peaked on day 125 and was lowest at term. These findings are consistent with 1) the onset of a steep rise in elastin accumulation during the canalicular period, 2) the development of a rigid, mainly collagenous structure of the central airways and blood vessels and a distensible peripheral “gas-exchange tissue,” rich in elastin, 3) an important role of elastin in the function of the visceral pleura, and 4) a peak of mitotic activity during the early alveolar period.
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Schellenberg, JC., Liggins, G. Elastin and Collagen in the Fetal Sheep Lung. I. Ontogenesis. Pediatr Res 22, 335–338 (1987). https://doi.org/10.1203/00006450-198709000-00019
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DOI: https://doi.org/10.1203/00006450-198709000-00019