Abstract
Pancuronium bromide during IPPV has been recommended as a means of reducing pneumothorax, fluctuations in cerebral blood flow velocity and ICH in newborns with RDS. Thirty-three preterm infants, requiring ventilation for severe RDS were randomly assigned to control and treatment groups. Group 1 (BW 1035 ± 197 g; G.A. 28,1 ± 1,86) breathed spontaneously. Group 2 (BW 1205 ± 164 g; G.A; 28,8 ± 1,76) was paralyzed uith pancuronium, bromide 0,1 mg/kg IV, PRN. IMV in the first group and IPPV in the second (Bear BP 2001) uere used to mantain a PaCO2 ≤ 45 mmHg and a PaO2 ≥ 50 mmHg.
The infants were kept muscle relaxed until they needed a FiO2 ≤ 0.4 and PI ≤ 15 cm H2O.
No significant difference in the incidence of major ICH, periventricular leukomalacia, pneumothorax, BPD, and mortality was found. Our data show no advantages using pancuranium bromide during mechanical ventilation in preterm newborn with RDS.
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Saia, O., Vozzi, A., Murer, L. et al. PANCURONIUM BROMIDE DURING MECHANICAL VENTILATION IN PRETERM INFANTS (BW ≤ 1500 g) WITH RDS. Pediatr Res 22, 242 (1987). https://doi.org/10.1203/00006450-198708000-00171
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DOI: https://doi.org/10.1203/00006450-198708000-00171