Abstract
Rubella revaccination (RA 27/3-Behringwerke, FRG) was given to 20 women (mean age 20 y) in order to study the effect of recurrent infection on the platelet associated (PA-) IgG, IgM, and C3. An antiglobulin consumption assay in a micro-ELISA technique was used at day 0,5,10,20, and 30. We observed neither thrombocytopenia nor adverse reactions on the vaccination. The rubella Ab titer rose from 1:24 to 1:28 (HHT, geometric mean).
The starting/highest levels (mean ± SD) were: PAIgG 6.5±4.3/12.2±9.0 (day 20 p.v.), PAIgM 4.7±2.6/13.3±9.7 (day 10 p.v.), PAC3, 2.0± .7/5.0±3.4 (day 20 p.v.). Using the paired t-test the differences were significant (p < 0.005).
The increase of platelet associated proteins did not reach levels found in acute ITP, but those seen in acute paediatric infection. Some of these proteins may represent Rubella specific immune complexes which have been demonstrated by others in sera of revaccinees at the appropriate times. In turn our data present another hint on a physiological role of the thrombocyte in removing immune complexes from the circulation.
Supported by DFG grant Fo 116/2-1
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Forster, J., Zinn, P. PLATELET ASSOCIATED PROTEINS AFTER RUBELLA RE-VACCINATION. Pediatr Res 22, 240 (1987). https://doi.org/10.1203/00006450-198708000-00160
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DOI: https://doi.org/10.1203/00006450-198708000-00160