Abstract
The aim of the study was to exam bacterial overgrowth/b.o./and bile acids/b.a./metabolism in children suffering fron coeliac disease/CD/and protracted diarrhea/DP/.
Material and methods: 115 children suffering from CD and DP, of 1-36 month of age, have been examined. The children were divided into groups according to the b.o. or normal gut flora/n/:CDbo=27, CDn=19;, DPbo=33, DPn=36. In duodenal fluid aerobes, anaerobes and yeasts were estimated. Serum b.a. were measured by RIA, duodenal b.a.-TLC, faecal b.a.-Sterognost 3-Pho.
Results:Bacterial overgrowth was found in 47.8% in DP and 58.7% in CD, mainly caused by Enterobacteriaceae and among then E.Coli. E.Coli was isolated in 60.7% in DPbo and 60.7% in CDbo. In duodenal fluid unconjugated and secondary b.a. were found in 5% of children. In all the investigated groups malabsorption of b.a. uas found-faecal b.a. over 270 umol/100g. In 34% fasting duodenal b.a. were below the critical micellar concentration/2nmol/L/. Fasting/(0'/serum b.a. were elevated in 56% in DP and CD considered together and postprandialy/120'/ in 46%.
Conclusions: 1. Bacterial overgrowth is a patogenic factor in DP and CD. 2. E.Coli in duodenal fluid cause prolongation and aggraviation of infant's diarrhea. 3. In both DP and CD bile acids malabsorption and liver failure are observed. 4, The estimation of microflora and b.a. give informations concerning prognosis and treatment among other MCT, but do not differentiate chronic diarrhea.
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Kulesza, E., Socha, J., Dzierzanowska, D. et al. MICROFLORA AND BILE ACIDS IN PROTRACTED DIARRHEA AND COELIAC DISEASE. Pediatr Res 22, 234 (1987). https://doi.org/10.1203/00006450-198708000-00126
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DOI: https://doi.org/10.1203/00006450-198708000-00126