Abstract
Supplementation of milk formulas with Ca and PO4 for prevention of osteopenia in very LBW infants(< 1500g) is generall accepted as necessary. The optimal performance is still discussed.
We therefore measured FR of ionised Ca and PO4 under inulin-clearance conditions in 14 LBW at conceptional ages(CA) from 32 to 40 weeks. Mean birth weight was 930 g and gestational ages at birt ranged from 29 to32 weeks. Ca and PO4 were added to standard formula(Beba O,Nestle) in capsules containing 60mg Ca and 20mg PO4 per 100ml milk. Resulting concentrations were 110 and 50 mg/100 ml for Ca and PO4. Vit.D was substituted with 1000U/d. Tubular reabsorption rates increased for both ions with maturation in parallel to increasing glomerular filtration rates. FR of Ca (Tc/Cin) remained constant over the range of CA measured(mean 1.16 ± 0.03 umol/ml). FR of PO4 increased with maturation from 1.07 to 1.85 umol/ml. Infants with lowest weight and CA had lowest serum levels of PO4 and lowest rates of FR.
Results: Need for increase of PO4 intake in very immature infants.
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Galaske, R., Peltner, U. ORAL SUPPLEMENTATION AND RENAL TUBULAR FRACTIONAL TUBULAR REABSORPTION(FR)OF CALCIUM AND PHOSPHATE IN VERY LOW BIRTHWEIGHT INFANTS(LBW). Pediatr Res 22, 233 (1987). https://doi.org/10.1203/00006450-198708000-00121
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DOI: https://doi.org/10.1203/00006450-198708000-00121