Abstract
CBF autoregulation is impaired after experimental S in the neonatal period; to analyse the effect of PB on this phenomenon, CBF is measured (microspheres) in the postictal period in 3 groups of newborn piglets (2 to 5 days old) following chemically induced S (bicuculline 1mg/Kg). 2 groups were treated with 20 mg/Kg of PB given either 3minutes (grI:n=6) or 15 minutes <grII:n=6) after the onset of S, 6 animals (grIII) not treated served as controls. In the 3 groups, CBF was evaluated after a complete desappearance of S assessed clinically and on EEG. After a baseline postictal determination of CBF, 2 measurements were performed at different values of mean arterial blood pressure within the normal range for autoregulation obtained with a graded hemorrhage.
Baseline postictal CBF was significantly lower in PB treated animals (grI; 59±11 ml/min/100g, grll: 56±17 ml/min/100g, mean±1SD) than in control group (85±24 ml/min/100g> p < 0.01. During graded hypotension, CBF was pressure passive in the control group (r = 0.55, p < 0.04) but not in PB treated animals (groups I and II). This suggest that treatment of S with PB reduce CBF and restore CBF autoregulation providing a protection against hemorrhagic and/or ischemic brain insult.
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Monin, P., Hascoet, J., Feillet, F. et al. Phenobarbital (PB) restores cerebral blood flow (CBF) autoregulation after seizures(S) in the newborn Piglet. Pediatr Res 22, 228 (1987). https://doi.org/10.1203/00006450-198708000-00092
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DOI: https://doi.org/10.1203/00006450-198708000-00092