Abstract
To investigate a possible influence of maternal pre-eclampsia on haemostasis in the neonate, blood coagulation and fibrinolysis were tested in 21 preterm infants (27-36 weeks gestation) born after maternal pre-eclampsia and in 16 healthy neonates, 10 preterm (32-36 weeks gestation), of uncomplicated pregnancies. A peripheral venous blood sample (1.5-2 ml) was taken within 8 hours after birth and analysed for activated partial thromboplastin time and plasma levels of fibrinogen, antithrombin III, prekallikrein, C1 esterase inhibitor, alpha-2-antiplasmin, plas-minogen, protein C and D dimer.
The levels of the various factors well agreed with normal reference values for the age and did not differ significantly between the two groups of preterm infants. Thus an influence of maternal pre-eclampsia on neonatal haemostasis could not be demonstrated. Significantly (P <0.01) lower levels of prekallikrein (29.2/37.7%), plasminogen (53.4/84.2%) and protein C (21/38%) in the preterm than in the term controls confirms a gestational age dependency of haemostatic factors.
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Faxelius, G., Dahlman, T., Hellgren, M. et al. Haemostatic factors in infants of preeclamtic mothers. Pediatr Res 22, 225 (1987). https://doi.org/10.1203/00006450-198708000-00074
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DOI: https://doi.org/10.1203/00006450-198708000-00074