Abstract
TNF is a cytokine released by activated monocytes exerting a number of reactions that may occur during HD (fever, neutropenia, monocytopenia, vascular endothelial lesions). We measured serum levels of TNF in 6 adolescents aged 14-21 years undergoing regular HD 5 min before and 15 min after start of the procedure with cuprophane membranes. Before HD TNF could not be detected in measurable amounts. In contrast, 5 of 6 sera taken after start of the HD session we found significant amounts of TNF (1045-7000 pg/ml serum). Our results suggest that TNF is released by HD. Therefore the above mentioned side effects of HD may be related to the action of TNF. The high TNF levels may also contribute to the development of autoantibodies or the persistance of cytotoxic antibodies in HD pts.
Supported by BMFT, Bonn, FRG, PTB#03 8397
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Eife, R., Müller-wiefel, D., Sigmund, B. et al. ELEVATED LEVELS OF TUMOR NECROSIS FACTOR (TNF) IN ADOLESCENTS ON HEMODIALYSIS (HD). Pediatr Res 22, 224 (1987). https://doi.org/10.1203/00006450-198708000-00065
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DOI: https://doi.org/10.1203/00006450-198708000-00065