Abstract
With the Phadebas IgE PRIST (modified to detect IgE up to 0,04 IU /ml)we have determined total CBIgE in 100 preterm newborns of varying gestational ages, in 47 term neonates with no atopic parentage, and in 390 at risk for atopy term neonates. IgE levels were also measured in males and females to evaluate possible differences between the two sexes. CBIgE (IU/ml, GM-2SD)were as follows. 0,009+0,71 in 7<28-wk-old, 0,045+1,2 in 54 28-32-wk-old, 0,052+1,66 in 39 33-37-wk-old, 0,041+1,05 in 47 term, and 0,295 + 5,12 in the 390 at risk neonates. There are no significant differences between preterm and term neonates. Newborns of atopic parentage have IgE levels significantly higher (p<0,0005) than the levels in neonates of not atopic parents. Males have CBIgE higher than females (p<0,025) in agreement with the higher incidence of atopy in males than in females. Even higher differences exist dividing both the 47 not at risk and the 390 at risk neonates according to sexes (p<0,0005). We stress that CBIgE can have very low levels, often lower than 0,5 IU/ml. It is therefore mandatory to use more sensitive tests when doing such studies.
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Betti, P., Largajolli, G., Zaramella, P. et al. SERUM CORD BLOOD (CB) IgE IN PRETERM AND TERM NEWBORNS. Pediatr Res 22, 222 (1987). https://doi.org/10.1203/00006450-198708000-00056
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DOI: https://doi.org/10.1203/00006450-198708000-00056