Abstract
It has been shown in animal model that CMPHs do not elicit any antibody response to cow's milk (CM) proteins as well as passive cutaneous anaphylaxis. In addition, babies fed with these formulas during the first months of life do not show antibodies to betalactoglobulin (BLG). All these data suggest that these formulas are not antigenic, therefore they have been employed as CM substitutes for the management of infants with CM allergy (CMA). We report here on 5 infants (4 males, 1 female) aged 3-8 mos (median age 5 mos) with IgE-mediated CMA, who experienced anaphylactic reactions when they were first fed with a small amount of a CMPHs (Alfa-Rè, Nestlé). Family history was positive for atopy in 3/5 babies. All infants had a slight atopic dermatitis during exclusive breastfeeding, positive skin tests and RAST to CM proteins as well as to Alfa-Rè. Moreover, total IgE levels were (GM) 199,5 + 5754,4 U/ml. In conclusion the data show that CMPHs can trigger severe anaphylactic reactions in children with CMA. Therefore they should be employed with great caution as CM substitutes in the management of CMA.
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Businco, L., Cantani, A. & Longhi, M. SEVERE ANAPHYLACTIC REACTIONS FOLLOWING COW'S MILK PROTEIN HYDROLYSATES (CMPHs) INGESTION. Pediatr Res 22, 222 (1987). https://doi.org/10.1203/00006450-198708000-00054
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DOI: https://doi.org/10.1203/00006450-198708000-00054