Abstract
α1-microglobulin (α1-M) is a low-molecular-weight protein easily filtered by the glomerulus arid almost completely reabsorbed and then catabolized in the proximal tubular cells. Urinary excretion of α1-M was determined in 48 diabetic children (28 females), aged 3-20 y (mean 12.1), duration of disease 1 week to 13 y (mean 6.1) and in 39 healthy controls (22 females), aged 4-19 y (mean 11.7). Urine was collected at high diuresis and the pH adjusted with 0.1% sodium azide to about 7.0; urine samples were stored at - 20°C for two weeks. α1-M urinary concentrations were measured by an Enzyme-Immuno-Assay (Fujirebio Inc., Japan). Urinary excretion of α1-M was significantly higher in diabetics than in healthy children (1.19±0.24 vs 0.99±0.21 ng/min; p<0.01); urinary excretion was greater in poor-controlled diabetics (stable HbA1c more than 10%) than in well-controlled ones (HbA1c less than 10 %) (1.30 ± 0.26 vs 1.11 ± 0.18 ng/min; p<0.05).
Urinary excretion of α1-M is a suitable method to detect tubular dysfuntion in type 1 diabetic children and adolescents.
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Chiarelli, F., La Penna, G., Anichini, M. et al. URINARY EXCRETION OF α1-MICROGLOBULIN IN CHILDREN WITH TYPE 1 (INSULIN-DEPENDENT) DIABETES MELLITUS. Pediatr Res 22, 218 (1987). https://doi.org/10.1203/00006450-198708000-00031
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DOI: https://doi.org/10.1203/00006450-198708000-00031