Abstract
A diminished vascular response to hypoxia has been demonstrated in type 1 diabetes (IDDM). This functional abnormality might be a phenomenon preceding the late structural vascular disease. In order to evaluate the prognostic value of this vascular dysfunction a prospective study has been started.
Vascular reactivity of skin vessels was evaluated as changes in transcutaneous PO2 at 37° C during postocclusive hyperemia (Clin Physiol 1984;4:413). All children in our county, acquiring IDDM 1983-4 (n=38) comprised the study group. Vascular reactivity was evaluated at admission before insulin therapy and then at 1, 6, 12 and 24 months after diagnosis. Vascular reactivity at admission (3.0±0.2 kPa, M±SEM) was impaired (p<0.001) but improved at one month (3.9±0.2) into the range of the control children (n=58) (3.9±0.1). Thereafter a deterioration was noted and at 24 months the vascular response to hypoxia (3.0±0.2) was as low as at admission. Age, sex or puberty was not correlated to the vascular response. Carbohydrate control, C-peptide, trace elements and lipids in serum were only weakly correlated to the degree of vascular dysfunction. The changes in vascular reactivity and carbohydrate control during the first years occurred in parallel but were not correlated. Other factors must be considered to explain the deterioration in vascular response to hypoxia after the initial normalization in childhood IDDM.
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Ewald, U., Kobbah, M. & Tuvemo, T. PROSPECTIVE STUDY OF VASCULAR FUNCTION IN CHILDHOOD IDDM. Pediatr Res 22, 218 (1987). https://doi.org/10.1203/00006450-198708000-00028
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DOI: https://doi.org/10.1203/00006450-198708000-00028