Abstract
We have shown an excellent correlation between plasma (P) and citric acid-stimulated saliva (Sal) theophylline concentrations (TC) (mean+/-SD PTC: Sal TC = 1.78+/-0.22, Fed Res. 20:1047, 1986; Pediatrics, in press).
We applied Sal TC determinations for T therapy monitoring by performing 93 Sal TC 24 h profiles in 59 ambulatory asthmatics (mean +/-SD age 8.3+/-3.2 ys) treated with slow release preparations (SR): 5-7 saliva samples were collected by parents at home during a 24 h period. Actual vs estimated PTC confirmed a possible mean error of only 0.83 meg/ml in these children. Sal TC were satisfactory in 40 children; therapeutic levels were achieved in 18 (30.5%) only after changing daily dose or dosing intervals; marked morning vs nighttime variation existed in both peak and trough Sal TC (p < 0.05) in 13 children. Highest Sal TC in a 24 h Period was in morning sanples in 86%, while lowest level was in evening samples in 84% of the children.
Conclusions: 1. Sal TC is extremely valuable in ambulatory asthmatics. 2. Routine 24 h peak level should be taken 3-4 after morning, and trough level before evening doses of SR.
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Tal, A., Aviram, M., Ben-Zvi, Z. et al. THEOPHYLLINE THERAPY MONITORING USING 24 H SALIVA THEOPHYLLINE CONCENTRATION PROFILES IN AMBULATORY ASTHMATICS. Pediatr Res 22, 217 (1987). https://doi.org/10.1203/00006450-198708000-00025
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DOI: https://doi.org/10.1203/00006450-198708000-00025