Abstract
We have compared vitamin D (vit D) metabolite, calcium (Ca), phosphorus (P) and alkaline phosphatase (AP) blood values in perroature infants fed human milk (mean birth weight 1478, range 645-1970, mean gestational age 31 weeks) receiving vit D 500 IU/d or 1000 IU/d with and without Ca (108 mg/kg/d) and P (53 mg/kg/d) supplementation. At 3 months of age the bone mineral content (BMC) of radius was measured by direct photon absorptiometry (125 I). In infants receiving 500 IU/d of vit D the mean 25(OH)D was 55.7ng/ml (n=18, SD 33.8) and 1,25(OH)2D 94.0 pg/ml (n=17, SD 44.8) at 3 months of age. The values for those with 1000 IU/d were 56.2 ng/ml (n=20, SD 32.1) and 120.0 pg/ml (n=18, SD 72.2), respectively (ns). Ca, P and AP values were followed up every two weeks and were equal in the two groups. No differences were seen in BMC between the groups with different vit D dose (115±35 mg /cm, n=6 vs. 113±39 mg/cm, n=5). On the other hand in infants without Ca and P supplementation BMC was significantly lower (67±6 mg/cm, n=3) than in those receiving supplementation (132±27 mg/cm, n=8) (p=0.005). Hypophosphataemia was common in the very low birth weight infants not receiving Ca and P supplementation. We conclude that 500 IU/d of vit D is enough for premature infants if Ca and P supplementation is taken care of. There is no advantage of a higher vit D dose for bone mineralization.
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Mäki, R., Ala-Houhala, M., Koskinen, M. et al. 87. BONE MINERALIZATION OF PREMATURE INFANTS DEPENDS ON CALCIUM AND PHOSPHORUS INTAKE AND NOT ON THE DOSE OF VITAMIN D SUPPLEMENTATION. Pediatr Res 22, 110 (1987). https://doi.org/10.1203/00006450-198707000-00108
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DOI: https://doi.org/10.1203/00006450-198707000-00108