Abstract
Potential toxicity of bilio-pancreatic secretions on oesophageal and gastric mucosa is wellknown in adults. Nevertheless DGR had never been assessed in children. After a 6 hours fast, we measured the following parameters by their one hour gastric outflow, collected with a naso-gastric tube : trypsin (TR), marker of pancreatic reflux, by radio-immunologic assay; phopholipids (PLP), i.e.lecithin and lysolecithins, markers of biliary reflux, by colorimetry; sialic acid (SA), marker of gastric mucus erosion, by Aminoff method. The measurements were done in 38 controls, divided into 3 groups : 0-2 months (n=8), 2-12 months (n=20), 1-4 years (n=10)
As in adults, DGR was defined by a value above mean plus 2 SD for one or the 2 bilio-pancreatic markers. In a preliminary study DGR could be demonstrated in 3 children, with an antral gastritis. The levels of the 3 parameters were then much higher than the definite standards. This non invasive method seems to be a very usefull approach for the diagnosis, mechanisms and treatment of gastric and oesophageal pathologies.
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Foucaud, P., Mouterde, O., Vatier, J. et al. 56. PHOSPHOLIPIDS AND TRYPSIN GASTRIC OUTFLOW: A MARKER OF DUODENO-GASTRIC REFLUX (DGR) IN CHILDREN. Pediatr Res 22, 105 (1987). https://doi.org/10.1203/00006450-198707000-00077
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DOI: https://doi.org/10.1203/00006450-198707000-00077