Abstract
whereas milk- (or formula-)feeding neutralizes the gastric content(pH>4), gastric pH monitoring can be used studying the gastric anacidity, and subsequently the gastric emptying, time (Sutphen, AJDC 1986;140:1062-1064).
Using a new technique, extended simultaneous esophageal and gastric pH monitoring, we measured the postcibal time gastric pH was > 4 in 11 asymptomatic infants according to a double-blind cross-over technique. Two isocaloric formulae with a different fat concentration were studied. The composition of both formulae (Fo1/ Fo2) is as follows (g/100ml): protein 2.2/2.2; Fat 2.6/3.6; Carbohydrates 8.2/7.6; Lactose 5.3/5.4.
The results of the esophageal pH monitoring were in all infants within normal ranges, but GER occured more in the postcibal period of infants receiving Fo2. The duration gastric pH was > 4, was significantly (P<0.001; Student's t-test) shorter in the infants receiving Fo1 (52 +/- 10 min) {mean +/- 1 SD) than in the infants receiving Fo2 (79 +/- 11 min). Whereas a delayed gastric emptying time has been reported as one of the causes of GERpathology (Hillemeier, J Pediatr 1981;98:190-193), the administration of a low-fat formula (milk) could possibly decrease the incidence of reflux by shortening the gastric emptying time.
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Vandenplas, Y., Loeb, H. 54. INFLUENCE OF THE FAT CONCENTRATION OF A FORMULA ON THE GASTRIC ANACIDITY TIME. Pediatr Res 22, 105 (1987). https://doi.org/10.1203/00006450-198707000-00075
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DOI: https://doi.org/10.1203/00006450-198707000-00075