Abstract
A radioimmunological method for measuring macromolecular absorption has been developed. Serum concentrations of human alpha-lactalbumin (LA) were measured after a meal of human milk. (1). The aim of the study was to measure macromolecular absorption in infants with CMA, and to compare the results with those in healthy infants. Serum samples were analyzed at 30 and 60 minutes after an intake of human milk. The results are expressed as ug LA/l serum/l human milk/kg body weight. Samples have been analyzed from 32 healthy infants of different age, from 16 infants with acute symptoms of CMA rind from 18 infants with suspected CMA during a challenge with cow's milk.
Infants with CMA who had either gastrointestinal or skin symptoms showed higher concentrations of LA than the control infants. Six infants with a clinically positive milk challenge showed increased serum concentrations of LA, while 12 infants with a clinically negative challenge did not.
Conclusion: Infants with gastrointestinal or skin symptoms due to CMA have an increased macromolecular absorption. Analysis of LA in serum during a milk challenge could be a valuable complement to the observation of clinical symptoms.
1) Jakobsson et al: Gut 27:1029-34, 1986.
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Juvonen, P., Jakobsson, I., Lindberg, T. et al. 19. MACROMOLECULAR ABSORPTION IN INFANTS AND CHILDREN WITH COW'S MILK ALLERGY (CMA). Pediatr Res 22, 99 (1987). https://doi.org/10.1203/00006450-198707000-00040
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DOI: https://doi.org/10.1203/00006450-198707000-00040