Abstract
We have investigated the development of sucrase-isomaltase (SI) activity in rabbit small intestine at the mRNA level. Rabbit SI cDNA was used as a probe (1). Spontaneous development was studied between 1 and 40 days of life. SI mRNA and enzymatic activities appeared simultaneously from day 15 onwards in untreated animals (2), matching one another for over two orders of magnitude. Same results have now been obtained in baby rabbits treated with glucocorticoid. Hormone-triggered precocious development was found at days 4 and 8 after daily injection of the steroid from birth. Our findings strongly suggest that the developmental control of SI complex is located mainly at the transcriptional level. Development of SI is presently being investigated in other systems as well.
1) W. Hunziker, M. Spiess, G. Semenza and H.F. Lodish (1986) Cell 227-234.
2) G. Sebastio, W. Hunziker, A. Ballabio, S. Auricchio and G. Semenza (1986) FEBS Letters 208, 460-464.
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Sebastio, G., Hunziker, W., Ballabio, A. et al. 15. ON THE PRIMARY SITE OF CONTROL IN SPONTANEOUS AND IN GLUCOCORTICOID-TRIGGERED PRECOCIOUS DEVELOPMENT OF SMALL-INTESTINAL SUCRASE-ISOMALTASE COMPLEX. Pediatr Res 22, 98 (1987). https://doi.org/10.1203/00006450-198707000-00036
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DOI: https://doi.org/10.1203/00006450-198707000-00036