Abstract
Intestinal amino acid transport in rodents decreases after birth. Simultaneously, changes of other function and structure occur and influence observed uptake rates. Thus, it is equivocally wether the decline is caused by a change of the transport system itself. Rates of uptake of L-phenylalanine into isolated brush border membrane vesicles(bbm) and into an intact mucosal layer(iml) were examined in newborn(n) and adult(a) rats. Uptake decreases significantly (p>.01) in bbm and iml after birth. Concentration dependent uptake suggests a non-saturable and a saturable component of transport of which constants were determined.
Results show a considerable change of the diffusional constants KO and the Vmax values during maturation. The change of Kt has only a small effect on the observed differences. This suggests an alteration of the membrane permeability, a decrease of the number of transport sites per unit surface, and an involvement of the brush border transport system in the process of maturating intestinal function.
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Nützenadel, W., Schwartze, E. & Suhr, A. 9. POSTNATAL MATURATION OF AMINO ACID TRANSPORT IN THE BRUSH BORDER MEMBRANE OF THE RAT. Pediatr Res 22, 97 (1987). https://doi.org/10.1203/00006450-198707000-00030
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DOI: https://doi.org/10.1203/00006450-198707000-00030