Abstract
Children initially imnunized with PRP or PRP-D conjugate vaccines between 15 and 24 months of age were assessed 1 year later for persistence of AB and response to revaccination with PRP, PRP-D, or normal saline (N=111). Pre and post-vaccination sera were obtained and anti-PRP antibodies were assayed by RIA. Adverse reactions were minor and noted in <5% of vaccinees. AB levels a year after initial immunization were significantly higher in subjects immunized with PRP-D(GM 1.12 ug/ml) than with PRP (0.22 ug/ml)(p<.0001). All groups demonstrated an increase in anti-PRP levels after revaccination, although this response was significantly greater in subjects initially immunized with PRP-D, regardless of booster vaccine given. Initial vaccine:
Children immunized with PRP or PRP-D between 15 to 24 months of age respond dramatically to reimmnunization one year later, although children previously immunized with PRP-D show the greatest responses even with conventional PRP antigen.
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Berkowitz, C., Ward, J., Hendley, J. et al. PERSISTENCE OF ANTIBODY (AB) TO HAEMOPHILUS INFLUENZAE TYPE B (HIB) AND RESPONSE TO PRP AND PRP-D BOOS-TER IMMUNIZATION IN CHILDREN INITIALLY IMMUNIZED WITH EITHER VACCINE AT 15 TO 24 MONTHS. Pediatr Res 21 (Suppl 4), 321 (1987). https://doi.org/10.1203/00006450-198704010-00926
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DOI: https://doi.org/10.1203/00006450-198704010-00926