Abstract
Elevated 1,25Dc repeatedly were found in premature infants. We investigated if high 1,25Dc 1) are accompanied by a high “free 1,25OH2D index” (FDI; ratio molar concentrations 1, 25OH2D/vitaminD-binding protein(DBP)) and 2) are induced by hypophosphatemia or hyperparathyroidism. Matched pairs of 14 premature infants (birth-weight 1430g, 980-1700g; x̄, range gestational age33weeks, 31-35weeks) were fed human milk with supplements of phosphorus (P) or calcium+P .VitaminD3, 1000 I.U./d were given. P,iPTH(midregional antibody), 25OHD(RIA), 1, 25Dc(RRA), DBP(radial immunodiffusion) and alkaline phosphatase (AP) were measured in serum at bodyweights 1800±75g(I) and 2150±75g(II), respectively. Results were not significantly different within pairs and therefore are indicated together as x̄±SD:
AP was normal in all samples. Both 1,25Dc and FDI were high when compared to adult reference values but occurred without hypophosphatemia or hyperparathyroidism.
The significance of high total and free 1,25Dc in premature infants and the mechanisms of its regulation remain to be elucidated.
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Schilling, R., Haschke, F., Schatten, C. et al. ELEVATED TOTAL AND FREE 1,25-DIHYDROXYVITAMIN D CONCENTRATIONS (1,25Dc) IN SERUM OF PREMATURE INFANTS. Pediatr Res 20, 1207 (1986). https://doi.org/10.1203/00006450-198611000-00200
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DOI: https://doi.org/10.1203/00006450-198611000-00200