Abstract
We have measured IAA titers in 113 children: 36 had newly diagnosed but untreated type I DM (group I), 53 were first-degree relatives of type I DM (group II), 24 had mild fasting hyperglycemia (110-135 mg/dl) and no familial history of DM (group III) .
After dextran-charcoal extraction of endogenous insulin, the binding of mono 125I-human insulin (200 μCi/mg) was determined in serum by PEG precipitation. Insulin binding (IB) averaged 1.02 ± 0.16 % (SD) in 35 healthy normoglycemic children (range 0.68 - 1.35). 14/36 of group I (39%) had IB higher than 5 SD ranging from 1.9 to 57% (average 11%).
1 patient in group II, aged 4 years had 14% IB, with high islet-cell antibody (ICA) titers (1/16) and decreased insulin response to IVGTT: 1' + 3' < 30μU/ml. He became diabetic the following weeks. Similarly 1 child of group III had 3.7% IB, elevated ICA (+ 1/10), and almost no insulin response to IVGTT. The child became insulin-dependent DM 2 months later. No other children of any group had IB higher than 1.4%.
The present prospective data confirm the significance and specificity of increased titers of IAA for prediction of type I diabetes mellitus.
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Bougnères, P., Castano, L., Chaussain, J. et al. INSULIN AUTOANTIBODIES (IAA) PREDICT OVERT DIABETES MELLITUS (DM) IN CHILDREN. Pediatr Res 20, 1205 (1986). https://doi.org/10.1203/00006450-198611000-00191
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DOI: https://doi.org/10.1203/00006450-198611000-00191