Abstract
7 children with growth retardation (m = - 3 ± 1 SD), with slow height velocity and partial GH deficiency in response to two pharmacological tests (maximum peak 11 ng/ml) received GRF for 6 months (10 mcg/kg/day) as a subcutaneous injection (8 p.m.). 24-hours GH secretion was studied before and after 3 months of treatment : SmC dosage and a IV GRF test (2 mcg/kg) was done before and after 6 months of treatment. Lower leg length was studied every 3 weeks by knernometry and statural growth at 3 months intervals.
Height velocity increased in 5 cases from 2.5 ± 0.5 to 4.4 ± 1.1 cm for the 6 months period and showed no change in 2 cases. Knemometric growth rate is subject to wide variations and is difficult to take into account. There was no sign of desensitization: 24-hour secretion (mx peak and I.C.) was higher after 3 months treatment (m = 16.2 ± 7.5 ng/ml and 3.7 ± 1.2 ng/ml/min before, 29 ± 17.9 ng/ml and 4.5 ± 2.9 ng/ml/min afterwards), as was the GH peak in the IV GRF test after 6 months treatment (m = 36.1 ng/ml before, 47.8 ng/ml afterwards). SmC level was higher on average after 6 months treatment (1.9 ± 1 U/ml and 0.8 ± 0.5 U/ml before treatment). The analysis of the various parameters (GH secretion, SmC) provided no elements to account for the lack of therapeutic response in the 2 cases. These results suggest that GRF treatment may be considered as a therapeutic alternative in GH deficiencies.
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Rochiccioli, P., Tauber, M., Coude, F. et al. RESULTS OF SIX MONTHS GRF TREATMENT: ANALYSIS OF GROWTH, SmC, 24-H GH SECRETION IN SEVEN CASES OF PARTIAL GH DEFICIENCY. Pediatr Res 20, 1190 (1986). https://doi.org/10.1203/00006450-198611000-00098
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DOI: https://doi.org/10.1203/00006450-198611000-00098