Abstract
Effects of Ethinylestradiol (EE) in girls with tall stature were assessed in a collaborative study of two centers comparing 38 girls (I), receiving 0.3 - 0.5 mg EE daily, with 44 girls on 0.1 mg EE daily (II). To minimize errors of height prediction (HP) bone ages (BA) were determined according to GREULICH and PYLE by using the mean of four determinations of both centers. Final height (FH) was predict according to the tables of BAYLEY and PINNEAU and was measured at a chronological age (CA) of 19.8 ± 1.2 years (y). Prior to EE administration the following findings did not differ (I vs II): CA (12.5 vs 12.4 y), BA (12.4 vs 12.4 y), length (+3,2 vs + 3.2 SDS) and HP (+3.8 vs +3.8 SDS). Evaluation of the differences between SDS of HP and SDS of FH showed no difference with respect to dose, however, an increased BA at the onset was correlated with a smaller reduction (Table I).
Cumulative dose (218±86 vs 64±20 mg), BA at the end (15±0.5 vs 15.9±0.5y) and growth after discontinuation of EE (2.7±1.8 vs 1.8±1.2 cm) did differ.
Conclusion: 0.1 mg EE is as effective as 0.3 mg EE daily.
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Grueters, A., Heidemann, P., Schlueter, H. et al. REDUCTION OF FINAL HEIGHT IN TALL GIRLS FOLLOWING ESTROGEN ADMINISTRATION IS NOT DOSE DEPENDANT. Pediatr Res 20, 1180 (1986). https://doi.org/10.1203/00006450-198611000-00037
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DOI: https://doi.org/10.1203/00006450-198611000-00037