Abstract
One of the more challenging problems in pediatric oncology is the management of children with inoperable, non-metastatic intraabdominal, retroperitoneal or pelvic malignancies. The conventional treatment of these children is the delivery of tumorincidal dose with external beam radiotherapy (EBRT) following surgery which is accompanied by significant short and long-term toxicity to normal tissues. Intraoperative radiotherapy (IORT) has the potential to overcome the limitations of conventional EBRT by limiting radiation exposure of normal tissues and therefore limiting radiation toxicity. Twenty-two age and weight matched adult female Beagles were subjected to laparotomy and IORT of the retroperitoneum with 6 MeV 0, 30 and 40 Gy (90% isodose line) to establish a range of normal tissue tolerance of the retroperitoneal structures to IORT. Up to two years no abnormal changes have been observed on histological examination of the aorta, vena cava, retroperitoneal soft tissue, except uretral fibrosis and stenosis and nephritis. IORT may be a new useful combined treatment modality in pediatric oncology.
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Hoekstra, H., Mehta, D., Humphrey, C. et al. 72 INTRAOPERATIVE RADIOTHERAPY. A NEW COMBINED MODALITY THERAPY IN PEDIATRIC ONCOLOGY?. Pediatr Res 20, 1045 (1986). https://doi.org/10.1203/00006450-198610000-00126
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DOI: https://doi.org/10.1203/00006450-198610000-00126