Abstract
Today, it is possible to identify the majority of the newborns with a high risk of atopy by recording family history (FH) and determination of cord-blood IgE (CB-IgE). But this selective screening cannot detect the total number of newborns at risk of atopy. The aim of the present study was to investigate the value of T-cell suppressor count in newborns for the prediction of atopy. We studied CB-IgE, T-cell counts and FH in 138 non-selected newborns. No measures were undertaken for the prevention of atopy. A control determination of IgE and T-cell function was performed at 14 months age.
All children with elevated CH-IgE and low T-Suppressor cell count in the cord blood (11%) developed clinical signs of atopy. The risk of atopy was significantly higher in children with low CB-T-suppressor cell count and pos. FH compared to normal controls (p 0,01). High CB-IgE or low T-suppressor cell count are of similar value for the prediction of atopy. At the age of 14 months, no correlation could be drawn between IgE, T-suppressor cell count and atopy symptoms.
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Bauer, C., Schlemmer, P., Franz, R. et al. 31 T-CELL RATIO IN NEWBORNS AND ONE YEAR OLD CHILDREN AT RISK OF DEVELOPING ATOPY. Pediatr Res 20, 1039 (1986). https://doi.org/10.1203/00006450-198610000-00085
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DOI: https://doi.org/10.1203/00006450-198610000-00085